PULSATILE DRUG DELIVERY SYSTEM: A NOVEL APPROACH FOR DRUG DEVELOPMENT
Saloni Narula* and Mahesh Kumar Kataria
ABSTRACT
The pulsatile drug delivery system offers various advantageous characteristics by delivery of the drug at the right time based on the circadian rhythm of the body. The basic principle for the use of pulsatile release of the drugs is where a constant drug release is not desired. A pulse has to be designed in such a way that a complete and rapid drug release is achieved after the lag time. This concept benefits many patients for the treatment of various diseases like asthma, arthritis, cancer, diabetes, hypertension, ulcer, hypercholesterolemia, congestive heart failure, stroke. This review paper aims to introduce the basic concept of chronotherapeutics, drug release mechanism, formulation types through different classification systems based on time-controlled, stimuli induced, external stimuli induced. This review also covers the marketed innovations of pulsatile drug conveyance like PulsincapTM, OROS, CODAS, 3D printing, CONTIN. Pulsatile drug delivery systems have the potential to bring new developments in the therapy of many diseases.
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