Abstract

Mohit Kumar* and Mahesh Kumar Kataria

ABSTRACT

Pharmacosomes are colloidal dispersions in which the drug is covalently bound to lipids and may persist as vesicular, hexagonal aggregates, or micellar relying on the atom arrangement of the drug-lipid complex. Pharmacosomes are a likely substitute for conventional vesicle methods. The encapsulation of the drug in the vesicle of small size and amphiphilic nature both enhances the retention of the drug in the systemic circulation of the body. The pharmacosomes enhance the cell wall transfer, improves the poorly water-soluble molecule’s solubility by ameliorating bioavailability and also reduces the toxicity of the drug. Pharmacosomes have successfully been prepared for numerous drugs such as non-steroidal anti-inflammatory drugs (NSAIDs), cardiovascular drugs and antineoplastic drugs. This review dealt with all facets of pharmacosomes such as composition, method of preparation, method of characterization/evaluations and their therapeutic application. The pharmacosomes containing the herbal drugs are referred to as phytosomes. Pharmacosomes offers emerging challenges and opportunities to improve novel vesicular drug delivery system for the superior efficacy of the administered drug.