Abstract

*Fareha Sadaf, Armughan Aymen Mastan, *K. Rama Rao and Anupama Koneru

ABSTRACT

The present study is aimed evaluated the anti-Parkinson’s activity of methanolic extract of Phyllanthus acidus (PAME) leaves in chlorpromazine(CPZ)-induced Parkinson animal model. The fruit extract was analysed to identify the phytochemical constituents present. Phytochemical screening revealed the presence of carbohydrates, steroids, saponins, triterpenes, phenols, flavonoids, and alkaloids. The anti-Parkinson’s activity was studied in CPZ (3 mg/kg) induced Parkinson animal model. Rats were subjected to treatment with PAME and standard for a period of 21 days.The animals were given the PAME extract in a concentration of 200 mg/kg and 400 mg/kg. The effects of Phyllanthus acidus were studied using in vivo behavioral parameters like catalepsy and locomotor activity and its effects on neurochemical parameters like Dopamine, Catalase, brain SOD, and GSH in rats.Histopathology of brain was performed. PAME (200mg/kg and 400mg/kg) treated groups significantly reduced catalepsy and improved locomotor activity. They also showed an increase in the levels of Dopamine, brain SOD, GSH and decreased lipid peroxidation. Thus, the study proved that Phyllanthus acidus treatment significantly attenuated the motor defects and also protected the brain from oxidative stress. So, it may be concluded that the extract of Phyllanthus acidus leaves demonstrated a good antioxidant and neuroprotective effect in chlorpromazine induced Parkinson animal model.