Abstract

Shailesh Dhamale*, Usha Bagal, Sangram Deshmukh, Shyamlila Bawage, Pingala Kadam and Yeshwant Aurade

ABSTRACT

Vinca alkaloids are acts as a antineoplastic drugs obtained from the “Madagascar Periwinkle plant and it is naturally extracted from the Periwinkle plant, Cathranthus roseus. Vinca is blue, purple and also white in colour and it is generally produce in summer and grown anywhere in the garden. The Vinca alkaloids have lots of medicinal value such as Anticancer drug (antineoplastic drug), antidiabetic, antimicrobial and acts as a disinfectant. Vinca alkaloids have hypoglycemic as well as cytotoxic effects and given in targeted and combination therapy. Anticancerous drug Vinca have ability to inhibit the cancerous cells. Vinblastine (VBL), Vincristine (VCR), Vinorelbine (VRL), and Vindosine (VDS) are the four major Vinca alkaloids but mainly two chemical constituents play a vital role in medicinal field as Vinblastine mainly used to treat Hodgkin lymphomas on the other hand Vincristine used to treat childhood leukaemias. Many times it causes toxic effects in our body such as bone, narrow depression and muscle weakness etc. Vinflunine is now a new synthetic vinca alkaloid. It is also helps in regulation of menstrual cycle. Vinca is known for its antitumour against diabetic, hostile to microbial and against the mutagenic impact.