Abstract

Yash Datta Kale* and Dr. Anuruddha Rajaram Chabukswar

ABSTRACT

Benzothiazoles are a group heterocyclic scaffold which have a benzene ring and a nitrogen(N) and sulfur(S) groups present in the pentacyclic ring structure which in combination gives rise to Benzothiazole ring. This benzothiazole ring structure is a parent ring structure for many pharmacological activities as anti-tubercular, anti-microbial, anti-malarial, anti-inflammatory, anti-cancerogenic activity, anti-convulsant activity., etc. this class of heterocyclic moiety show some similarity with penicillin, carbapenems, cephalosporins classes as the functional group in the parent ring is similar but the atomic configuration is different. There are various uses of the benzothiazole ring but we are interested in anti-tubercular activity. In this article, there will be detail understanding of structural activity relationships of the parent ring and also there are variety of synthesis discovered but one very specific to it is discussed later.