Abstract

Md. M. Alam*, S. Rahman, J. Ferdous, Md. R. Tahsin, Ahmemed U. Faisal, Monirul I. Daimond, Md. A. Rouf, A. Saha, Samia N. Tahiti, Ahmad U. Faisal, Jakir A. Chowdhury, S. Kabir, Abu A. Chowdhury, F. Aktar, T. Akter and Md. S. Amran

ABSTRACT

Diabetes mellitus (DM) is a disorder caused by improper glucose, protein, and lipid metabolism. It is caused by insulin insufficiency, which is frequently accompanied by insulin resistance. Plants have long been an excellent source of medications, and many of the drugs that are currently available were produced directly or indirectly from them. The Phylanthus emblica plant is said to have anti-diabetic effects as well as other health benefits such as increased immunity, improved skin and eyesight, improved liver, heart, and brain function, and so on. In this study, the antidiabetic activity of Phylanthus emblica plant in alloxan induced diabetic rats was evaluated against metformin. Here, rats were kept in lab for 7 days for habituating them in the lab environment and treatment period was 42 days. Alloxan was given in fasting condition in a dose of 150 mg/kg/body/day weight and 14 days were waited after administration of alloxan. For the evaluation of antidiabetic activity, body weigh, blood sugar level, liver function (SGPT &SGOT level), creatinine and urea level were tested. The ethanolic extract of P. emblica fruit has a promising anti-diabetic impact on the animal model (p0.05/p0.01), but only in a dose-dependent way. The lower dose of P. emblica was found to be significantly capable of restoring the altered physiological state (p0.05). A higher dose of P. emblica, on the other hand, has better anti-diabetic therapeutic effects. This study found that different doses of P. emblica extracts have comparable therapeutic effects to established marketed medications in the treatment of hyperglycemia.