International Journal Of Modern
Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Science & Pharmacy Professional

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2319-5878
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Abstract

FORMULATION AND EVALUATION OF OIL IN WATER NANOEMULSION OF MOXIFLOXACIN FOR OPHTHALMIC DELIVERY

*Shivani Tiwari, Jitendra Banweer, *Durga Pandey

ABSTRACT

Our aim is to prepare & evaluate Moxifloxacin nanoemulsion of for ocular delivery. We hypothesized that our developed delivery system will result with improved drug retention in cornea, sustained release will be achieved and dosing frequency will be reduced as compared with conventional products. Drug identification done by UV FTIR, melting point and solubility. Nanoemulsion prepared by standard procedure with minor modifications. Particle size was found around 380 nm by Malvern analyser. SEM Showed droplets spherical shape and size 300 nm. % entrapment was 81 %. Microscopy also showed drops oval to spherical in shape. Marketed formulation released 100 % within 30 min where as optimized nanoemulsion was released in sustained manner for more than 6 hrs. Thus it can be concluded that designed formulation can be able to improve drug activity.

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