MOLECULAR DETECTION OF CYP2C19*2 GENE POLYMORPHISM AMONG SUDANESE PATIENTS WITH TYPE 2 DIABETUS MELLITUS IN KHARTOUM STATE
Shereen M. A. Mahyeldin*, Eman Osman, Salaheldein Elzaki, Huda Fdlelmula, Nadia M. Madni, Babeker Ahmed Mohammed
ABSTRACT
Background: Diabetes mellitus is a global pandemic disease it is complicated by vascular occlusion. Studies indicated that in these patients platelet indices showed platelet increased activity as well as that the polymorphism of the cyp2c19*2 gene contributes to the state of DM thrombophilia. Aim: This study was aimed to detect cyp2c19*2 gene polymorphism in type2 diabetic Sudanese patients. Methodology: A total of 148 diabetic Sudanese patients were enrolled in this study. 2.5ml of peripheral blood using PCR analysis for cyp2c19*2 polymorphism for genotyping and 2.5 ml peripheral blood in EDTA for complete blood count in particular platelet indices. Results: The freuency of cyp2c19*2 for (AA, GA, GG) was (52%, 41%, 5%), (36%, 55%, 8%) respectively for controlled and uncontrolled patients. In association of age with genotype show statistical significance P. value
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