Abstract

*Poonam Yadav, Durga Pandey, Praveen Tahilani and R. B. Goswami

ABSTRACT

The objective of this work was to prepare and evaluate emulgel of Piroxicam which will increase skin penetration of drug due to penetration enhancers in comparison with marketed preparations of the drug. Droplet’s size of emulsion was found 759 ?m. The drug content found to be 98.1 in the gel and viscosity 20211 ± 0.43 cP spreadibilty of formulation was more than marketed formulation. Optimized formulation showed 83.1 % release in 8 hours which is little more than marketed preparation. Emulgel are more comfortable than cream and ointments. Materials selected for preparation are biocompatible in nature. Piroxicam will be highly effective drug in the treatment pain, swelling, and joint stiffness from arthritis. Its analgesic activity can be improved by adding methyl salicylate, mentha oil and clove oil in the formulation. Mentha oil and clove oil used for permeation enhancers in the formulation for better drug absorption. More drug will be absorbed by emulgel than conventional formulation and reduces dosing frequency. We can conclude that Piroxicam is more effective when entrap as microemulsion and given in emulgel form as compared to conventional dosage form of the same drug.