Abstract

Chandra Sekhara Rao Nethinti*, Bhaskar Rao Bytapally, Sreenivasulu Boju, Raghu Babu Korupolub and Annapurna Nowduri and Uttam Kumar Ray

ABSTRACT

Isoproterenol hydrochloride 1 is used for the treatment of mild or transient episodes of heart block, bronchodilator and Adams-Stokes attack. During the process development of isoproterenol hydrochloride, two process related impurities, 4-[1-methoxy-2-[(1- methylethyl)amino]ethyl]-1,2-benzenediol hydrochloride (7) and 4-[1-isopropoxy-2- [(1-methylethyl)amino]ethyl]-1,2-benzenediol hydrochloride (8) were identified and these are not reported anywhere and reported herein for the first time. The present work describes the identification, synthesis and spectral characterization of these impurities.