Abstract

Upasana Saikia*, Sheikh Sofiur Rahman and Chinmoy Bhuyan

ABSTRACT

Delivery of drugs to the mucosal sites of the body may be beneficial for various reasons. Delivery of a mucosal drugs achieves a therapeutic effect as the permeation of sufficient amounts of a drug is permitted through the absorption membrane. The in-vitro and in-vivo models are required for the assessment of the delivery potential of such novel drug delivery systems, such as nanoparticles, and for explaining the mechanisms related to the drug delivery enhancement. This system exhibits various functions and features like mucoadhesive and protective activity, solubility improving, permeation and uptake enhancing, and drug release controlling properties. Drug delivery through mucosal surfaces including airways, gastrointestinal tract and the genital tract, represents a desirable delivery by injection. Administration of a drug by injection is expensive and is time consuming, and overall pain decreases the patient compliance.[1] The mucosal route is gaining attention for drug delivery via the oral, nasal, pulmonary or vaginal routes. It includes advantages, limitations of oral mucosal drug delivery system. Nanoparticles for mucosal drug delivery system have been found to be likely advantageous in terms of many features since they: a) decreases the dosing frequency, b) increase the bioavailability of anti-HIV drugs, c) enhance physicochemical properties of drugs such as less solubility as well as stability and d) decreases the adverse effects.