Abstract

*Sanjay Kumar and Shalini Singh

ABSTRACT

Peptic ulcer is acid-induced injury of intestinal system that is generally situated in stomach or upper segment of duodenum. It has been characterized by bared mucosa with imperfection stretching out into sub-mucosa. Few previous literatures indicates that anti-ulcer effect of Morus alba has been evaluated using extractions obtained using alcohol solvent. So, this research focuses on pharmacological screening of anti-ulcer potential of hydroalcoholic leaves extract of M. alba in albino rats. The extraction of the same was done by maceration process using hydroalcoholic solution (1:1) for better and optimum release of chemical constituents. Pylorus-ligation, cold restraints and forced swimming models were used to determine the anti-ulcerogenic activity. Various parameters were evaluated such as pH determination, volume of gastric content, free acidity, total acidity and various microscopical studies. In the models, M. alba leaf extract (hydroalcoholic) showed a significant anti-ulcer effect when compared to control group and for standard group (Ranitidine 20mg/kg). The effect as anti-ulcerogenic was seen in the dose dependent manner. In conclusion, hydroalcoholic leaves extract (HLE) of Morus alba is effective as anti-ulcer at both the doses. But effect was optimum in the dose of 400mg/kg than 200mg/kg. It suggests, to identify and isolate the responsible moiety for this anti-ulcer activity and to convert into suitable dosage form.