BRONSTED ACID PROMOTED FOR THE SIMPLE AND EFFICIENT BIOACTIVE SYNTHESIS OF BIS (INDOLYL) METHANE DERIVATIVES.
P. Sateesh, D. Divakhararao, D. Durgarao, D. Radhika and Dr. S. Srinivasrao
ABSTRACT
This work presents a highly an efficient and simple method for the synthesis of bis(indolyl)methanes employing an efficient, mild and inexpensive methane sulfonic acid catalyst was used for the synthesis of derivatives of 3, 3?- (Phenyl methylene)bis (1H-indole)from indole and substituted aromatic aldehydes in protic solvent under reflux condition. The titled compounds confirmed by advanced spectral data (1HNMR, 13NMR & LCMS) and also structure of the compounds determined by elemental analysis.This method is an environmentally benign, efficient reaction, requires shorter reaction time and simple experimental and workup procedures.
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