Abstract

Dr. Rajesh M. Kharate*

ABSTRACT

Series of 3-thio-4-aryl-5-phenyl-imino-[1,2,4]-dithiazolidines have been synthesised by the interaction of ammonium aryl dithiocarbamates with N-phenyl-S-chloro isothiocarbamoyl chloride under microwave irradiation followed by the basification with dilute ammonium hydroxide solution. These compounds were synthesized also by conventional heating for comparison. Initially ammonium aryl dithiocarbamates have been prepared by the interaction of different amines with carbondisulphide and ammonium hydroxide. Constitution of synthesized compounds have been delineated on the basis of chemical transformation elemental analysis, equivalent weight determination, IR and 1H-NMR spectral studies. The title compounds were evaluated for their antimicrobial activity against the microorganisms like S. typhi, E. coli, B. subtilis and S. aureus.