SYNTHESIS AND BIOEVLUATION OF SERIES OF 2-(4-BROMOPHENYL)-2-METHYL-N-PHENYLPROPANAMIDE ANALOGUES
S. Shyam, Ch. Syamala, K. Satya Baba, Sunil Kumar, S. Pydiyya and Dr. N. Krishnarao*
ABSTRACT
A series of six Synthesis of 2-(4-bromophenyl)-2-methyl-N-phenylpropanamide derivatives were synthesized by condensation of substituted aromatic primary amines with 2-(4-bromophenyl)-2-methylpropanoylchloride in the presence of strong base such as triethyl amine in DCM at 400C. This compound can be synthesized 2-(4-bromophenyl)-2-methylpropanoylchloride from 2-(4-bromophenyl)-2-methyl propionic acid with thionyl chloride in the presence of DCM at0-100C. All the five compounds can be confirmed by advanced spectral data (1HNMR, 13CNMR & LCMS) and the structure of the all compounds can be determined by elemental analysis. All the derivatives were evaluated, by antibacterial activity.
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