Abstract

Fawzia Zakaria El-Ablack*, Samuel Tanas Melek, Faten Mohamed Zahran, Rehab Mukhtar Abdel Salam

ABSTRACT

Background: The early diagnosis of osteoarthritis is required to do possible intervention in early stage of disease because it is one of the leading causes of disability in advance stage. Aim: For this reason, this study aimed to investigate the relationship between the various biomarker anti-cyclic citrullinated peptide (anti-CCP) levels, Serum concentrations of N-terminal telopeptide of type I collagen (NTX), as bone resorption marker, alkaline phosphatase (ALP) and osteocalcin (OC) as bone formation markers, vitamin D, Calcium and phosphrous.in patients with osteoarthritis (OA). Methods: ninety patients with AO were included in the study. Enzyme-linked immunosorbent assay (ELISA) was used to detect Anti-CCP antibodies, NTX, OC and vitamin D. C reactive protein (CRP), phosphorus total and ionized calcium. 3.1. Age and Gender Distribution: There was statistically significant difference between OA group and that of healthy group in addition, OA group included 70 cases of females but control group included 20 cases of males and females, there was statistically significant difference between two groups. Results: Among cases with negative anti-CCP group, NTX showed a significant positive correlation with OC, Anti-CCP, ALP, Phosphorus and a negative correlation with Vitamin D, Total calcium and CRP. Moreover, OC showed a significant positive correlation with Anti-CCP, ALP, Phosphorus, While the negative correlation appeared significantly with Vit D, total and ionized calcium. Among cases with positive anti-CCP group, NTX showed a significant negative correlation with osteocalcin. Osteocalcin correlates negatively with vitamin D and ionized calcium. Patients in the highest of serum NTX concentrations showed the fastest rate of bone loss. Conclusion: Serum NTX may provide a clinically relevant serum assay to estimate bone turnover in OA patients.