Abstract

Asmaa El-Rakhawy*, Nabil El Adeb, Ahmad Darwish, Gamal M Dahab and Dr. Mohamed Abd-elaziz

ABSTRACT

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer worldwide. Like other types of cancer, leukemia is a multi-genic, multifactorial, and complex disease. MAPK (Ras) pathway is supposed to be vital in the development of leukemia. Mutations in the Ras gene and consequently high Ras proteins are highly prevalent in leukemia. The Ras pathway remains open as a result of activator mutations. This leads to carcinogenesis by producing uncontrolled proliferation signals in the lymphoblast. Additionally, there is a strong relationship between the high abnormal proteins of Ras pathway in ALL and in vitro cellular resistance to chemotherapeutics, the unfavorable patient's criteria, as well as worse outcome.