Abstract

Chinmoyee Borah*, Akash Ajith and Bishwa Narayan Kondoli

ABSTRACT

Cancer can be thought of as a disease that affects cell communication. Cancer is caused by genetic and epigenetic changes that allow cells to overproliferate and bypass survival and migratory pathways. Breast cancer is the most frequent cancer among women all over the world. The process of cell transduction is crucial in the formation and progression of cancer. Tumor cell proliferation, advancement, and survival are aided by changes in multiple cell signalling pathways. Various pathways are there which are involved in various cellular processes. Aberrant regulation of these pathways leads to cancer. This review looks at several of the cell signalling pathways like MAPK pathway, PI3K/AKT/mTOR pathway, NF-kB pathway, JAK-STAT Signaling Pathway, Hedgehog Signaling Pathway, Notch Signaling Pathway, Wnt Signaling Pathway, and their links to cancer, focusing on how abnormal signalling in these pathways can lead to breast cancer. Targeting various molecular events of these pathways provide treatment strategy for breast cancer.