Abstract

Saber El-Hanbally*, Hanem El-Gendy and Amera Abd El Latif

ABSTRACT

The present study was designed to determine the pharmacokinetics, bioavailability and tissue residues of marbofloxacin (10mg/kg.b.wt.) in ducks. Forty Molar ducks were divided into two groups. Blood samples were collected at 5, 15, 30 minutes, 1,2,4,6,8,12 and 24 hours after marbofloxacin administration. Serum marbofloxacin concentrations were determined by using high performance liquid chromatography (HPLC) technique. The serum concentration-time curve indicated a two compartment open model. Following a single intravenous injection, distribution half-life (t0.5?) was 1.04 ± 0.16h, volume of distribution (Vdss) was 6.71 ± 0.46 L/kg, elimination half-life (t0.5?) was 5.51 ± 0.61h and total body clearance (CLtot) was 0.66±0.02l/kg/h. Following a single oral administration, marbofloxacin had a peak serum concentration (Cmax) 1.60±0.03?g/ml at a time (tmax) of 1.69±0.03 h, elimination half-life (t0.5el) was 2.73±0.07h indicating the tendency of ducks to eliminate marbofloxacin in slow rate. Oral bioavailability was 79.68± 2.62% indicating good absorption of marbofloxacin after oral administration. Tissue residues of marbofloxacin in slaughtered ducks were high in those tissues; lung, kidneys and liver tissues so ducks should not be slaughtered before 3 days of stopping of marbofloxacin administration.