Abstract

*Gurumel Singh Kannaujiya and N. Trilochana

ABSTRACT

The liver is a vital organ in the human body that performs a variety of functions including metabolism, immunity, digestion, detoxification, and vitamin storage, to name a few. In the United States, drug-induced liver injury accounts for almost half of all occurrences of acute liver failure. This study was based on the pharmacological screening of antioxidant and hepatoprotective potential of hydroalcoholic leaves extract (HLE) of Pedalium murex in Wistar albino rats & in-vitro. The leaves of Pedalium murex were obtained from the Unnao reason, UP. It was identified and authenticated by a botanist. The leaves were washed making dust-free and dried in shade at room temperature and extracted by soaking into hydroalcoholic solution: Ethanol + distilled water (1:1) for fifteen days with gradual stirrings. The relative humidity was maintained at 44-56% and are fed with standard rodent diet and water ad libitum. Rats were divided into group 1 (normal saline), group 2 (Isoniazid 50mg/kg), group 3 (Isoniazid 50mg/kg + Silymarin 100mg/kg), group 4 (Isoniazid 50mg/kg + HLE of Pedalium murex 200mg/kg) and group 5 (Isoniazid 50mg/kg + HLE of Pedalium murex 400mg/kg). Activity was evaluated using different parameters i.e., estimation of total antioxidant activity, estimation of SGOT, SGPT, TB and serum lipid levels, determination of SOD activity and assay of lipid peroxidation. In results, P. murex significantly exhibited hepatoprotective effects in all the parameters when compared with Isoniazid control rats. It was found effective at both the doses 200mg/kg and 400mg/kg when tested in albino rats. In conclusion, hepatoprotective action of P. murex might be due to its antioxidant action and healing of hepatocytes (liver cells). It also suggests to identify and isolate the significant responsible chemical constituent that acted in this context of cure.