Abstract

*Harshit Yadav, Vikas Srivastav and Amresh Gupta

ABSTRACT

In the Ayurvedic system of Indian medicine, intranasal therapy has long been considered as a viable treatment option. Nasal medication administration is a good option for treatments that are effective at low doses but have low oral bioavailability. This review was focused on the polymers used, characterizations, advantages and limitations with herbs used in nasal formulations. Data was collected published in PubMed, Web of Science and various reputed platforms. The nasal route avoids the hepatic first-pass elimination that occurs with oral distribution, and it is simple to use and self-administer. Nasal drug delivery systems include nasal drops, nasal sprays, nasal gels and nasal powder. Various characterization parameters were used to evaluate such as pH, viscosity, isotonicity, drug content etc. Nasal formulations have numerous advantages i.e., fast delivery, self-administration, better patient compliance with some various limitations too. In conclusion, nasal spray medicine products are non-pressurized dispensers that provide a spray containing a metered dose of active component that is dissolved or suspended in solutions or mixes of excipients. Spray pattern, droplet size distribution, and Spray Content Uniformity are all critical characterization tests for nasal sprays that are affected by formulation and device parameters.