Abstract

*Nidhi Raturi, Popin Kumar and Praveen Kumar Ashok

ABSTRACT

According to Centres for Disease Control and Prevention, Rheumatoid Arthritis (RA) is an autoimmune and inflammatory condition in which your immune system unintentionally assaults healthy cells in your body, leading to inflammation (painful swelling) in the body areas affected. This review was emphasized on the process of preparation, polymers used, benefits & demerits and applications of nanogel. Rational treatment aims to reduce inflammation and relieve discomfort generally. Nonsteroidal anti-inflammatory drugs (NSAIDs), which include acetylsalicylate (Aspirin), naproxen (Naprosyn), ibuprofen, and etodolac are medications that are regarded as fast-acting. Nanogels (nanosized hydrogels) are small, swelling particles formed of adaptable hydrophilic or amphiphilic polymer networks that have been mechanically or chemically cross-linked. Ionic or anionic polymer networks are also possible. Benefits of cutaneous drug delivery include sustained action, dose flexibility, less adverse effects, the potential to avoid hepatic first pass metabolism and protection against drug inactivation by gastro-intestinal pH and enzymes. Nanogels are prepared by the two processes, i) physical crosslinking, ii) chemical crosslinking- inverse polymerization method. Polymers are used in development of nanogel including albumin, pullulan, hyaluronic acid, methacrylated chondroitin sulphate, chitosan, poly (N-isopropylacrylamide), poly (N-isopropylacrylamide-co-acrylic acid) and poly (ethylene glycol)-b-poly (methacrylic acid). It concludes that development of nanogels are essential and beneficial fast efficient drug delivery and quick relief from the pain of Rheumatoid Arthritis (RA).