Abstract

*Pragya Mishra, Pallavi Tiwari and Manoj Kumar Mishra

ABSTRACT

Fear, dread, and unease are all symptoms of anxiety. It can make you sweat, feel restless and tight, and cause your heart to race. Women are more likely than men to acquire emotional anxiety during adolescence. Every year, around 700,000 people die by suicide. Suicide is the fourth highest cause of death among those aged 15 to 29. The present research focuses on pharmacological screening of anxiolytic and antidepressant effect of hydroalcoholic flower extract (HFE) of Hippeastrum vittatum in Wistar albino rats. The flowers of Hippeastrum vittatum was obtained from the NBRI, Lucknow region and extracted by maceration in hydroalcoholic solution- Ethanol + distilled water (1:1) for fifteen days with gradual stirrings. Parameters- Elevated Plus Maze (EPM), Light/dark arena test, FST and Actophotometer were utilized. In screening of anxiolytic and antidepressant potential, Hippeastrum vittatum demonstrated significant decrease in anxiety and depression in rats when compared with control. In conclusion, hydro-alcoholic flower extract (HFE) of Hippeastrum vittatum is significant anxiolytic and anti-depressant herbal drug. It can be effectively used in the treatment of depression, mental agitation and other neurological disorders after successfully evaluating mechanism of action of the plant- flower.