Abstract

Banoth Reddy, Dr. N. Srinivasa Rao, B. V. Durgarao, V. Suresh Gowd and Dr. N. Krishna Rao*

ABSTRACT

The highly versatile and an efficient synthesis of 2,4,5-trisubstituted imidazoles is obtained by three component cyclocondensation of 1,2-dicarbonyl compounds, substituted aromatic aldehydes and ammonium acetate in thermal solvent free condition using Brønsted acidic methane sulfonic acid as catalyst. All the compounds were evaluated by advanced spectroscopic data (1H NMR, 13C NMR& LCMS) and the structural determination of the novel derivations was calculated by elemental analysis. The main focus of this process is cost effectiveness of catalyst, easy work-up and purification of products by non-chromatographic methods, good to excellent yields and very short time reactions. Multicomponent reactions were encouraged an outstanding status in synthetic organic and medicinal chemistry for their high degree of atom economy and application in the diversity oriented convergent synthesis of complex organic moiety from simple and readily available substrates in a single vessel. In the present study, ten hybridized imidazoles derivatives were synthesized via cyclo condensation and evaluated for their invitro antimicrobial activity and antioxidant properties.