BIOACTIVE, SYNTHESIS SERIES OF 4-(INDOLYL)-6-METHYL-2-THIOXO-1, 2, 3, 4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE EMPLOYING METHANE SULFONIC ACID
Dr. D. V. L. Sirisha, B. V. Durgarao, V. Suresh Gowd, Dr. Sheik Lakshman, Dr. V. Narasingarao, Dr. N. Krishna Rao*
ABSTRACT
The present study, the synthesis of series a novel 4-(indol-3-yl)- 6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-yl) ethanone from the reaction of substituted indole -3-carbaldehydes (1.152 mmol), acetyl acetone (1mmol), thiourea(2 mmol) in the presence of two new catalyst methane sulphonic acid at RT conditions. All the compounds were characterized by advanced spectroscopic data (1H NMR, 13C NMR& LCMS) and the structural determination was calculated by elemental analysis. In addition to the all newly synthesized compounds were evaluated by their microbial activity.
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