Abstract

Asish Bhaumik*, S. Chaitanya Kumar and Bilal Ahmed

ABSTRACT

Dihydropyridine is a pyridine which has had two H atoms added to the ring. As a result it has only two double bonds in the ring rather than three and it is NOT aromatic. The dihydropyridine ring is the basis for making several drugs which are commonly used for treating hypertension and angina. 1, 4-Dihydropyridine (DHP), an important class of calcium antagonist, inhibits the influx of extracellular Ca+2 through L-type voltagedependent calcium channels. Three-dimensional (3D) structure of calcium channel as a receptor for 1, 4-dihydropyridine is a step in understanding its mode of action. Protein structure prediction and modeling tools are becoming integral parts of the standard toolkit in biological and biomedical research. So, homology modeling (HM) of calcium channel alpha-1C subunit as DHP receptor model was achieved. The 3D structure of potassium channel was used as template for HM process. The resulted dihydropyridine receptor model was checked by different means to assure stereochemical quality and structural integrity of the model. This model was achieved in an attempt to understand the mode of action of DHP calcium channel antagonist and in further computer-aided drug design (CADD) analysis.