Abstract

Deepa Kumari A.* and Chitra M.

ABSTRACT

Due to misuse of antibiotics, bacteria are leading to an increase in multidrug resistance, thereby making the search for antibiotics from plants an effective and alternative approach imperative. In the present study, Costus pictus was selected for evaluation of antimicrobial activity against ESBL producing clinical isolates and additionally, biofilm inhibitory activity was determined with plant extracts. The results of phytochemical screening of Costus pictus leaf extract indicate the presence of Alkaloids, Flavonoids, Saponins Tannins and Phenols. The agar well diffusion method was utilized for the antimicrobial activity; the high polar extract of methanol showed greater activity then acetone extract. The methanol extract had a good battle against E. coli and K. pneumoniae. Furthermore, Costus pictus extracts had a good capacity to reduce biofilm formation. Further research is needed to understand which compounds found in the extract are responsible for the observed effects, including their respective modes of action.