Abstract

*Danave Rahul Dinkar, Dr. Arshu Pirmhommad Patel, Dr. Ravindra Sahadu Jadhav and Gadade Ashok Bhagwan

ABSTRACT

Antibiotics are a vital weapon for fighting bacterial infections from several decades. Numbers of antibiotics are not used therapeutically and clinically due to their resistance. Nowadays many bacteria have become resistant to common clinically used antibiotics. Uncertainty has arisen, as microbes have become resistant to common antibiotics while the host remains unaware that antibiotic resistance has emerged. The aim of this review is to explore the origin, development, and the current state of antibiotic resistance, regulation, and challenges by examining available literature. We found that antibiotic resistance is increasing at an alarming rate. A growing list of infections i.e., pneumonia, tuberculosis, and gonorrhea are becoming harder and at times impossible to treat while antibiotics are becoming less effective. Antibiotic-resistant infections correlate with the level of antibiotic consumption. Non-judicial use of antibiotics is mostly responsible for making the microbes resistant. The bacteria with multiple drug resistance have limited treatment and also are difficult to treat which may cause patient death.