Abstract

Ezhilarasi M., Ajith S., Vigneshwaran L.V.* and Senthil Kumar M.

ABSTRACT

To boost the bioavailability of various controlled drug delivery systems (CDDS), there has been a recent focus on administering medications through the buccal mucosa. In this context, mucoadhesion—the ability of an object to stick to mucous membranes—holds a special place. API delivery via the buccal cavity offers a practical method of administration for both systemic and local activities. Direct entrance into the systemic circulation prevents hepatic first-pass action and gastrointestinal tract degradation. However, the oral mucosa's permeability is a limiting factor because it is less than that of the skin and intestinal mucosa. The buccal membrane is shown to be more permeable when differences in permeability between various oral area organs are taken into account. It is necessary to lessen the mucosa's barrier potential to transport a wider range of medication classes over the buccal mucosa. This requirement forced researchers to investigate buccal penetration enhancers that could get through the buccal mucosa's permeability barrier. Many substances, such as bile salts, surfactants, fatty acids, and their derivatives, ethanol, cyclodextrins, and chitosan, have been tested for their ability to increase penetration. This review's objectives are to define the structural and chemical makeup of the buccal mucosa's permeability barrier and to explain how buccal penetration enhancers work.