International Journal Of Modern
Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Science & Pharmacy Professional

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2319-5878
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Abstract

METHOD DEVELPOMENT OF NIACIN IN BULK AND DOSAGE FORM BY UV-VISIBLE SPECTROPHOTOMETER

Dr. K. Bhavyasri*, B. Anila, S. Saileela, Dr. MogiliSumakanth

ABSTRACT

A simple and specific UV spectroscopic method has been developed using methanol and double distilled water as solvent to estimate niacin content in pharmaceutical dosage formulation. The ? max of niacin 260 nm.The linearity in the concentration range of 2?g/ml-10?g/ml was exhibiting good correlation coefficient(R2=0.9976). the results of the study proved the applicability of the present method in routine analysis of niacin in pharmaceutical dosage form. Niacin inhibits directly and noncompetitively inhibits hepatocytediacylglycerol acyltransferase-2. The inhibition of TG synthesis by niacin results in accelerated intracellular hepatic apo B degradation and the decreased secretion of VLDL and LDL particles.

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