Abstract

*Tanushi, Aparna Joshi, Kapil Kumar, Deepak Teotia, Ikram and Deepti Khairya

ABSTRACT

Spanules are the doses form having one API or more than one API in the form of granules, with a specific coating having a slow dissolving rate which alters the release pattern of the medicament in the Spanules ata different and predetermined time. Metformin is viewed as a enemy of hyperglycemic drugs as it brings down blood glucose fixation in type 2 diabetes without causing hypoglycemia. A through preformulation study has been performed on given sample in order to estimate the physiochemical properties like solubility, melting point to confirm authencity of sample and to conform that there are no significant barrier to the development of spansules. Evaluation parameters also have been studied to estimate the effect of spansules. An attempt was made to formulate and evaluate the Metformin spansules containing Metformin Hcl as a model drug. Prepared formulations were evaluated on different parameters like flow property, morphology, average weight, disintegration test and dissolution test. Study cocludes successful delivery of metformin by the means of spansules.