Abstract

Arun Kumar, Aparna Joshi, Kapil Kumar*, Deepak Teotia, Ikram and Deepti Khairya

ABSTRACT

The poorly water-soluble medication ketoconazole may be successfully incorporated into niosomes with high entrapment efficiency use of thin-film hydration process. The extended-release of the medication from the niosome raises the possibility that it will reduce side effects and frequency of administration. The drug's reduced size and vesicular form, which also boosted its penetration through the stratum corneum, improved the drug's localization in the stratum spinosum, where the infected macrophages are located, and its absorption by the infected macrophages.