International Journal Of Modern
Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Science & Pharmacy Professional

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2319-5878
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Abstract

FORMULATION OF HERBAL MEDICATED MONOLITHIC MATRICES USING EXTRACTS OF AZADIRCHATA INDICA (NEEM)

Sourabh S. Malabade*, Shirish S. Patil and Dr. Shitalkumar S. Patil

ABSTRACT

The current research work was aimed with an objective to formulate Herbal medicated monolithic matrices using extracts of Azadirchata indica (Neem) & to evaluate therapeutic efficacy of prepared matrices by in vitro anti-inflammatory & antibacterial activity. Herbal medicated monolithic matrices using Methanollic extracts of Azadirchata indica (Neem) were developed with different concentrations of sodium CMC by solvent evaporation technique. Three transdermal patch formulations (F1, F2& F3) consisting different concentrations of Sodium CMC were prepared. All formulations carried Tween-80 as penetration enhancer and PEG-400 as plasticizer in water and methanol (1:1) solvent system. The prepared transdermal patches were evaluated for their physicochemical characteristics such as physical appearance, weight variation, thickness, folding endurance, percentage moisture absorption, percentage moisture loss, water vapour transmission, tensile strength. In- vitro anti-inflammatory activity of prepared transdermal matrices is observed by recording inhibition of protein denaturation. Antibacterial activity of the prepared patches is evaluated against pathogenic strain of Staphylococcus aureus.

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