Abstract

Md Musharraf Ali* and V. Saikishore

ABSTRACT

The aim of present research work is to formulate and evaluate controlled release floating tablet of Famotidinein view to enhance bioavailability and therapeutic action. The tablets were formulated by employing wet granulation method using PVP K 30 as binder and isopropyl alcohol as granulating fluid. The granules were evaluated for flow properties. All the formulations showed values within the prescribed limits for tests like hardness, friability and weight variation which indicate that the prepared tablets are of standard quality. All the tablets were formulated using sodium bicarbonate as effervescent agent. All the prepared formulations floated immediately after placing into the beaker and the floating was maintained more than 14 hrs. It was observed that the carbon dioxide generated from sodium bicarbonate in presence of dissolution medium(0.1N HCL) was trapped in the polymer gel matrix formed by the hydration of polymer which decreases the density(0.5) indicted that the drug release was predominantly controlled by non fickian diffusion. Based on the release rate constant and % of drug release the formulations prepared with Cashew nut tree gum shown prolonged retarding nature compared with the formulations prepared with Aegle marmosa gum. Among all the formulations , F3 formulation containing drug and Cashew nut tree gum in 1:1.5 ratio was found to be optimized formulations.