A RESEARCH ARTICLE ON SYNTHESIS OF BROMOMETHYLATED NITROALKENES AS AN INTERMEDIATE FOR THE SYNTHESIS OF ANTICANCER AGENTS
Suman Lata Mehta*, Dr. Amarjeet Singh and Amrita Singh
ABSTRACT
Bromomethylatednitroalkenes were prepared from nitroalkenesby Baylis–Hillman reaction. These bromomethylatednitroalkene can be convereted into aromatic nitro compounds which are investigated to have toxic effects on bacteria, parasites, or tumor cells and can be developed as chemotherapeutic agents. Baylis–Hillman reaction is a carbon-carbon bond forming reaction between the ?-position of an activated alkene and a carbon electrophile such as an aldehyde in presence of nucleophilic catalyst such as a tertiary amine and phosphine. We have planned to synthesize novel 3-nitro substituted 1-aryl naphthalenes and 6-nitro substituted 4-arylbenzofuran and benzothiophene, aziridines from bromomethylatednitroalkenes via aziridines. Aromatic Nitro compounds can be used as anticancer agents due to selective toxicity on tumor cells.
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