Abstract

Tejas J. Patel*, Dr. Abdul Mannan Khan, Dr. Dhiren P. Shah

ABSTRACT

This research study was aimed to developed nanosponges loaded topical gel of mometasone furoate with purpose of to reduce particle size, increase permeation of drug, decrease systemic side effects, reduce dose frequency and enhance diffusion performance than conventional form. Organoleptic properties, Melting point, FTIR and DSC was carried out for identification of drug & to check interaction between drug & polymers. Preformulation study of drug showed that drug was pure and further take for formulation development. Nanosponges were prepared by Emulsion solvent diffusion method. From the evaluation of all batches of nanosponges which shows good % yield, drug content and loading efficiency. Among all the results F-3 batch shows a highest % yield, drug content and loading efficiency compare to other five batches. So, it was taken further for preparation of nanosponge loaded gel. Optimized F-3 nanosponge loaded topical gel of momentane furoate was prepared by using carbopol and it show 94.02% drug content and 83.84% drug release at 12 hrs. Formulated gel shows an excellent spreadability, viscosity, and ex-vivo drug release 81.09 % at 12 hrs. No skin irritation was seen in rat skin and no other changes in product was seen during stability study. So, Mometasone furoate nanosponge loaded gel may be decent choice for control release of drug for prolonged period of time at targeted site with avoiding systemic side effects.