Abstract

Eswari Beeram* and Prof. K. Thyagaraju

ABSTRACT

RNases plays a pivotal role in biological system as an enzyme and different RNases are known for their various functions like angiogenesis, immunological response, antiviral, antitumour activity and apoptosis. In which anti tumour activity of RNase is necessary to improve genome stability in normal cells up to major extent along with other factors. RNases like RNase L shows antiviral and antitumour activities against virus infected cells and cancer cells through 2’-5’ oligo adenylate pathway, and induces RNaseL dependent apoptosis. Where as RNase A modulates various proliferative pathways like MAP kinase, JNK, TGF-? and activates apoptosis in cancer cells and promotes immunological response against viruses through processing of Ags. IRE1 RNase acts as tumour suppressor and as well as oncogene in normal and cancer cells. RNase III up regulates miRNA in cancer cells there by acting via posttranscriptional level and proven to be effective against colorectal adeno carcinoma. Recently drugs like metosartan is found to induce deleterious effects in normal subjects compared to hypertensive subjects and most of the work in these days is at the Chemotherapy level in order to patients but targeting of proteins like enzymes together with chemotherapy may be useful and hope to be expected by next century.