Abstract

Gomase V.S.*, Kemkar K.R., Baviskar B.A., Mundhe V.S., Sakhare A.D., Kolsure A.K., Bhimanwar A.A., Dhamane S.P. and Potnis V.V.

ABSTRACT

Neurotoxin can cause body paralysis or even death due to respiratory failure. Neurotoxin Bmk-M8 from Scorpio Mesobuthus martensii is used to find out potential binding peptides. In this assay, we used PSSM and SVM algorithms to determine antigenic epitopes and predicted the binding affinity of toxin protein having 64 residues, which shows 56 nonamers. In addition we have predicted the hydrophobic secondary structure and solvent accessible structure of M. martensii Bmk-M8. Binding ability prediction of antigen peptides to major histocompatibility complex (MHC) class I & II molecules is important in vaccine development from Mesobuthus martensii Bmk-M8.