BUCCAL FILM: A NOVEL TECHNOLOGY FOR IMPROVING THE BIOAVAILABILITY
Bogavalli Varalakshmi, Boyeekati Mohammad Rizwan, Nagireddygari Prasanthi, Mule Pravallika, Redyam Mohan Reddy, Chinthaginjala Haranath* and Hindustan Abdul Ahad
ABSTRACT
Buccal film is an innovative form of film. The buccal drug delivery system is used to provide buccal film. Buccal film is a graceful and effective dose form that improves absorption by avoiding the hepatic first pass metabolism. It is more appropriate than other dose forms because it adheres to the buccal layer of the oral cavity in a suitable way. It is affordable, biodegradable, easy to grip, non-irritating, and does not require the patient to ingest the medication. Buccal film is a convenient dosage form that is tiny in size, dose, and easy to deliver. Solvent casting, hot melt extrusion, and direct milling are the main methods used to create buccal film formulation. Ingredients of buccal films are drug, film forming polymer, plasticizer, saliva stimulating agent, sweeting agent, flavouring agent, and surfactant. Buccal film is a pioneering dosage because of its wide use of advantages to elderly, paediatric as well as patients having swallowing issues. The application of buccal film includes cough, allergy, pain disorder and certain local oral disease condition can be treated by using drug in the form of buccal film. Buccal film is capable area for continued research with the goal of systematic delivery of orally inefficient drugs. It is alternative source for non-invasive delivery of strong peptide and protein drug molecules. Buccal film is buccoadhesive drug delivery system which enhances safety, efficacy and stability of active pharmaceutical ingredient. Buccal film is novel technology due to its superior option to improve therapeutic efficacy.
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