Abstract

Changala Kavya Sree, Thimma Reddy Gari Likhitha, Chinnarappa Gari Hima Bindu, Chinthamani Krishna Chandrika, Kasigari Harika, Chinthaginjala Haranath* and Hindustan Abdul Ahad

ABSTRACT

Floating In situ gel is a novel drug delivery system that maximizes the oral absorption of the drugs. Floating In situ gelling systems are liquid at room temperature but undergo gelation when in contact with the body fluids. Floating In situ gel-forming drug delivery is a kind of mucoadhesive drug delivery system. Different approaches involved in producing the floating in-situ gel formation are based on physical changes, chemical changes, and physiological stimuli. Floating In situ gel formulation is mainly prepared by the gelation method. Materials of floating in situ gels are drug, gelling polymer, cross-linking agent, buffering agent, and gas generating agent. Many natural, biodegradable, synthetic, and biocompatible polymers like sodium alginate, pectin, xyloglucan, Gellan gum, guar gum, etc are used in the preparation of floating in situ gelling systems. Gastro retentive floating in situ gel-forming system provides a suitable way for controlling drug delivery within the stomach where an environment-specific gel-forming solution, floats on the surface of gastric fluids. Floating In situ gelling system has several advantages over conventional drug delivery systems like the sustained and prolonged release of drugs, reduced administration frequency, improved patient compliance, ease of administration, and effective cost. It provides a more effective surface area than the tablet and it leads to an increased release and Improves availability. Floating in situ gels were used to treat the diseases like gastritis and other local infections related to GI the tract.