A REVIEW ON SELF NANO EMULSIFYING DRUG DELIVERY SYSTEM
Chandana L.*, Snehalatha, Subhan Sab, Nagaraja T. S. and Chethan Patel D. N.
ABSTRACT
A large proportion of novel pharmacologically active molecules developed in recent drug discovery programmes are lipophilic and poorly soluble, posing a significant challenge for pharmaceutical researchers to improve the oral bioavailability of such drug molecules. Among the different approaches, SNEDDS has received more attention due to improved oral bioavailability, which allows for dose reduction. SNEDDS is an isotropic mixture of oil, surfactant, co-surfactant and drug that forms an oil-in-water emulsion in aqueous environment under gentle agitation. Low energy emulsification tmethods and high energy emulsification methods can both be used to create nano emulsions. The self nano-emulsifying drug delivery system (SNEDDS) can improve the water solubility of poorly water soluble drugs in BCS classes II and IV. This review describes composition, preparation of components, mechanism of self emulsification, biopharmaceutical aspects and evaluation of self nano-emulsifying drug delivery system(SNEDDS) for enhancement of oral bioavailability of poorly water soluble drugs.
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