Abstract

*M. V. Kushnareva, E. A. Yurieva, V. V. Dlin, E. S. Vozdvizhenskaya

ABSTRACT

The development of oxidative stress with a predominance of oxidative activity is characteristic of all diseases. Significant pathological disorders in the redox system are especially characteristic in childhood due to the immaturity of the enzymatic component of antioxidant defenses. The oxidative "flash" is physiological in nature, as it is necessary for adaptation to the exposure at the beginning of the stress effect on the body. This protective reaction can lead to the depletion of the components of the antioxidant system with excessive oxidative stress, which is accompanied by damage to cells and tissues and the development of a pathological process. The phenomenon of antioxidant cooperative chains in mitochondria to protect cells from oxidative stress is considered. The emerging imbalance in the redox system justifies the replacement therapy with the use of antioxidants. The possibility of using herbal medicines in children with diabetes is being considered. The paper presents studies on the use of antioxidants in children with diseases of the respiratory tract and the cardiovascular system, with Computer Vision Syndrome, with nephrological and neurological pathologies, and with hereditary diseases. The clinical efficacy of Dimephosphone, Polyoxidonium, Mexidol and Skulachev ions is discussed. The question of the side effects of antioxidants, the duration of their use and possible combinations is considered.