SYNTHESIS AND ANTIOXIDANT ACTIVITY OF INDOLIZINE DERIVATIVES
Prof. Basavaraj M.*, Karthika Paul, Shanthala M., Shankar S. J.
ABSTRACT
A novel indolizine derivatives were synthesized by using indolizine 1- carboxylate and substituted 1,3,4-thiadiazoles. Indolizine 1-carboxylate were synthesized by using methyl acrylate and pyridinium halide in presence of manganese dioxide, triethylamine and toluene as a solvent. Substituted thiadiazole were prepared by reacting thiosemicarbazide with substituted carboxylic acid. Synthesized derivatives were screened for scavenging activity against 1,1 (DPPH). The results have showed that compound (4a) exhibited reasonable antioxidant activity. The structure of all the synthesized compounds were established by IR, NMR and Mass spectral data.
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