Abstract

Chidananda V.*, Yogananda R., Chethan Patel D. N., Snehalatha and Nagaraja T. S.

ABSTRACT

The solubility and bioavailability were major challenge for the pharmaceutical industry with development of new formulations. About 40-50% available marketed drugs are water insoluble. Various techniques are used to increase the aqueous solubility, dissolution rate, and bioavailability of poorly water soluble drugs include micronization, chemical modification, pH adjustment, solid dispersion, complexation, co?solvency, hydrotropy etc. The liquid-solid technique is a novel and promising method for altering the dissolution rate of drugs that are insoluble in water by blending with selected powder excipient, liquid medications such as solutions or suspensions of water insoluble drugs in suitable non-volatile liquid vehicles can be converted into acceptably flowing and compressible powders according to the new liquisolid compacts formulation method. Liqui-solid technology or powdered solution technology change the liquid drug into non-sticky, dry free-flowing, rapid release powder. This liquisolid technique enhances the solubility and dissolution of water insoluble drugs by increased wetting properties and surface area of drug available for dissolution. Liquisolid system is characterized by flow behavior, wettability, powder bed hydrophilicity, solubility, drug content, DSC, FTIR, powder x-ray diffraction, SEM, in-vitro drug release.