Abstract

*Arathi M. R. and Ramesh S. S.

ABSTRACT

Introduction: Organophosphates compounds are commonly used in the agriculture as an insecticide. Organ phosphorus compounds are one of the most common causes of insecticide poisoning worldwide leading to high degree of morbidity and mortality. The primary mechanism of action by OP and carbamate insecticides is the inhibition of acetylcholinesterase (AchE), an enzyme that catalyzes the hydrolysis of the neurotransmitter acetylcholine. The liver is the main organ that metabolizes various compounds including toxins, chemicals and drugs and eventually excretes from the body. The toxicity of organophosphorus compounds is mediated by generation of free radicals which may alter the liver metabolism and is evidenced by changes in level of its enzyme. This study aimed to determine liver transaminases (AST and ALT) and bilirubin levels to assess the severity of poisoning in patients with acute OP and carbamate poisoning. Materials and Methods: This was a retrospective study, and data was collected with the help of medical records department. This study included patients with organophosphate poisoning admitted between AUGUST 2020 and DECEMBER 2021 at a dedicated tertiary hospital in MYSURU, KARNATAKA Results: Mean age was 44: Males 58.66%, Females 41.3% Mild cases were 21, moderate cases were 37, severe cases were 17. Total 2 patients died. Mean ALT levels mild cases were 32.82 (8.52), moderate cases were 45.03 (12.41), severe cases were 48.90 (19.07) with p value 0.002. AST level in mild cases were 37.65 (6.49), moderate cases were 45.03 (12.41) and severe cases 53.80 (18.59) with p value