Abstract

*Priya Singh, Dr. Dilip Agrawal and Mohit Khandelwal

ABSTRACT

The objective of this research was to develop an intra gastric floating drug delivery system of Ramipril hydrochloride and also effort were made to sustain its release. Multiple-unit floating beads of Ramipril hydrochloride were prepared from sodium alginate solution containing polaxamer 188 by using foam technology method. These beads were evaluated for entrapment efficiency, drug loading, buoyancy and in vitro drug release. All formulations were the floating lag time below Four Second and shows total floating duration more than 15 hours. It was observed that entrapment efficiency, drug loading and buoyancy was greater with formulation containing sodium alginate 375 mg and 1% calcium chloride solution along with 100 and 150 mg polaxamer. Result of in-vitro dissolution studies reveals that the formulation B1 give sustained release pattern of Ramipril hydrochloride upto 15 hrs.