International Journal Of Modern
Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Science & Pharmacy Professional

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2319-5878
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Abstract

DEIGNED BIOACTIVE SYNTHESIS OF N-(5-(4-METHOXYPHENYL) THIAZOL-2-YL) BENZAMIDE ANALGUEOUS PROMOTED BY CDI /ET3N.

M. Siva Kumar, Dr. D. V. L. Sirisha and Dr. N. Krishna Rao*

ABSTRACT

An efficient and convenient multi step procedure has been described for N-(5-(4-methoxyphenyl) thiazol-2-yl) benzamide analgueous which can be obtained from the reaction of 5-(4-methoxyphenyl) thiophen-2-amine and substituted aromatic carbonyl halides in the presence of CDI /Et3N as solvent at reflux. 5-(4-methoxyphenyl) thiophen-2-amine can be obtained from2-bromo-1-(4-methoxyphenyl) ethan-1-one with thiourea in the presence of sodium acetate and acetic acid at 60-700C. All the compounds were evaluated by advanced spectroscopic data (1H NMR, 13C NMR and LCMS) and the structural determination was evaluated by elemental analysis. Besides to this, all the newly synthesized compounds were examined for their antibacterial activities and antifungal activity by disc diffusion method against the organism of Aspergillus Niger and Candida albicans.

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