Abstract

P. Kishore Kumar, K. Bhaskara Rao, M. Divya and Dr. N. Krishnarao*

ABSTRACT

We have in the present in depth study, an efficient and cost-effective process for the synthesis of derivatives of 7,7-dimethyl-4-phenyl tetrahydroquinazaloine- (1H,3H)-2,5-diones using dimedone, urea and substituted aromatic l aldehydes employing methanesulphonic acid as catalyst as well as solvent free condition. The structures of the desired compounds were analyzed by 1H-NMR & 13CNMR, Mass spectral as well as elemental analysis. The activities of an antimicrobial study of the titled compounds were also examined by vaious strains and exhibited mild to moderate anti-bacterial and anti-fungal activities.