International Journal Of Modern
Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Science & Pharmacy Professional

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2319-5878
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Abstract

DEIGNED SYNTHESIS AND BIOEVLUATION OF 4-ARYL BENZELIDENE-2-((5-FLUORO-1H-INDOL-1-YL) METHYL) OXAZOL-5(4H)-ONE PROMOTED BY KIO4.

B. Moulika Lakshmi, V. Narasinga Rao, L. Uma Maheswari and Dr. Krishna Rao*

ABSTRACT

A great deal of work has been done on the series of five series of 4-arylbenzelidene-2-((5-fluoro-1H-indol-1-yl) methyl) oxazol-5(4H)-ones. These derivatives were prepared from the condensation of 2-(2-(5-fluoro-1H-indol-1-yl) acetamides) aceticacd, substituted aromatic aldehydes with acetic anhydride sodium acetate and sodium acetate in the presence ofKIO4 under reflux. Five series novel new derivatives. 2-(2-(5-fluoro-1H-indol-1-yl) acetamides) acetic acid was obtained from 2-(5-fluoro-1H-indol-1-yl) acetyl chloride with lysine in the presence of NaOH and HCl in the ice cold solution. 2-(5-fluoro-1H-indol-1-yl) acetyl chloride can be synthesized from 5-fluoro indole with chloroacetyl chloride in triethylamine and dichloromethane. The structures of the compounds were confirmed by advanced spectroscopic data based on 1H-NMR, 13CNMR and LCMS and by elemental analysis. This compound was screened by anti-microbial activity.

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