FORMULATION AND EVALUATION OF FILM FORMING GEL OF PUMPKIN LEAVES EXTRACT FOR ANTIBACTERIAL ACTIVITY
Bhavya Shree T.*, Shravya K., Shreya D. Shetty, Shreya J. Poojari, Shriram H. Patkar and Sindhura Pallavi
ABSTRACT
Bacterial infection of the skin is one of the most common dermatological problems. Delivery of drugs to the skin is an effective and targeted therapy for local dermatological disorders. In the present study film-forming gels of pumpkin leaves extract were formulated for treating bacterial infections of the skin. The extraction of pumpkin leaves was done by maceration method and from the extract two different film forming gel formulations were prepared by using Carbopol 934 as gelling agent, PVP & PVA as film formers and other additives. The prepared film-forming gel formulations were evaluated for physical appearance, pH, viscosity, spreadability, extrudability, drying time to form film, thickness and antibacterial activities. The formulations exhibited satisfactory results for the evaluated parameters. Both formulations found to show satisfactory antibacterial activity i.e 20±0.81mm(F1) and 19±0.47mm (F2). By considering these factors it was concluded that the film-forming gels containing pumpkin leaves extract can be used for the treatment of bacterial infections effectively.
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